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Ozempic

Natty
fat lossweight losscardiovasculardiabetesoralsubcutaneous

What It Does

Reduces appetite and slows digestion for 15-21% weight loss. Improves blood sugar control. Lowers heart attack and stroke risk by 20%.

Natty Status Classification

This peptide is generally considered within the natty realm by some in the fitness community, particularly when used for therapeutic healing purposes. However, opinions vary, and competitive natural bodybuilding organizations may have different stances. Always check your federation's specific rules if you compete.

Description

FDA-approved GLP-1 agonist (Ozempic/Wegovy/Rybelsus) with 15-21% weight loss and 20% cardiovascular risk reduction. Nausea common, NAION risk noted.

Full Description

Semaglutide is an FDA-approved GLP-1 receptor agonist with 94% structural homology to human GLP-1, manufactured by Novo Nordisk as Ozempic (diabetes, 0.25-2mg weekly injection), Wegovy (obesity, up to 2.4mg weekly injection), and Rybelsus (diabetes, 3-14mg daily oral).

Activates GLP-1 receptors in the gastrointestinal tract, pancreas, and brain to reduce appetite, delay gastric emptying, increase insulin release, and lower glucagon secretion.

STEP trials demonstrated 14.9-17.4% mean weight loss at 68 weeks (2.4mg dose), with 69-79% achieving ≥10% weight loss.

STEP UP trial showed 20.7% weight loss with 7.2mg dose at 72 weeks.

SELECT cardiovascular outcomes trial showed 20% reduction in major adverse cardiac events (HR 0.80) in patients with obesity and preexisting cardiovascular disease but without diabetes.

FDA-approved March 2024 for reducing cardiovascular death, heart attack, and stroke risk.

Also approved for metabolic-associated steatohepatitis (MASH).

Most common side effects are gastrointestinal (nausea affecting up to 20%, vomiting, diarrhea, constipation), typically transient and mild-to-moderate.

Notable concerns include possible gastroparesis, 85% increased risk of non-arteritic anterior ischemic optic neuropathy (NAION), and thyroid cancer warnings from rodent studies (though human incidence <1%).

Available in both injection (89% bioavailability) and oral forms (0.4-1% bioavailability).

Gradual titration over 12-16 weeks minimizes gastrointestinal side effects.

What is Lyophilized Powder?

Lyophilized powder is a sterile, freeze-dried medication that must be reconstituted (mixed with a liquid solvent, like sterile water) before it can be injected. This process extends the drug's shelf life and stability, making it ideal for temperature-sensitive products. The lyophilization process removes water from the peptide in a frozen state through sublimation, which preserves the physical and chemical properties until it is needed.

Application Methods

  • Subcutaneous injection
  • Oral

Product Names

  • Ozempic
  • Wegovy
  • Rybelsus

Benefits

  • Weight loss 14.9-20.7% depending on dose (STEP trials)
  • 69-79% achieve ≥10% weight loss, 51-64% achieve ≥15%
  • 20% reduction in major adverse cardiovascular events (SELECT trial)
  • Reduced cardiovascular death, heart attack, and stroke risk
  • Improved blood glucose control and HbA1c reduction
  • Enhanced insulin sensitivity and reduced glucagon
  • Delayed gastric emptying and appetite suppression
  • Benefits in heart failure patients (HR 0.72 for MACE)
  • Metabolic-associated steatohepatitis (MASH) treatment
  • Available in oral (Rybelsus) and injectable forms

Dosage Levels

  • Injectable - Week 1-4: 0.25mg once weekly (subcutaneous)
  • Injectable - Week 5-8: 0.5mg once weekly
  • Injectable - Week 9-12: 1.0mg once weekly
  • Injectable - Week 13+: 2.0mg (Ozempic) or 2.4mg (Wegovy) maximum
  • Injectable - Higher dose: 7.2mg weekly (experimental, 20.7% weight loss)
  • Oral Rybelsus - Days 1-30: 3mg daily on empty stomach
  • Oral Rybelsus - Days 31-60: 7mg daily
  • Oral Rybelsus - Day 61+: 14mg daily maximum
  • Take oral form with ≤4oz water, wait 30 min before eating
  • Gradual titration over 12-16 weeks reduces GI side effects

Research

Where to Buy

*Peptides are stored in form and need to be reconstituted with sterile bacteriostatic water before use.

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Last Updated: 10/19/2025