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TB-500

Natty
healingrecoverytissue repairanti-inflammatoryinjectablesubcutaneous

What It Does

Speeds wound healing, muscle and tendon recovery. Reduces inflammation, improves joint mobility, minimizes scar tissue formation.

Natty Status Classification

This peptide is generally considered within the natty realm by some in the fitness community, particularly when used for therapeutic healing purposes. However, opinions vary, and competitive natural bodybuilding organizations may have different stances. Always check your federation's specific rules if you compete.

Description

Synthetic peptide based on thymosin beta-4 promoting tissue repair, wound healing, and muscle recovery through actin regulation. Strong animal research, limited human data. Not FDA-approved.

Full Description

TB-500 is a synthetic 43-amino acid peptide modeled after thymosin beta-4 (Tβ4), a naturally occurring protein found throughout the human body that plays critical roles in tissue regeneration, wound healing, and inflammation modulation.

Its primary mechanism involves binding to actin, a protein essential for cell structure and movement, thereby promoting cell migration, angiogenesis (new blood vessel formation), and tissue remodeling.

TB-500 has demonstrated significant potential in preclinical studies for accelerating soft tissue repair, enhancing wound closure, improving cardiovascular function post-injury, supporting muscle and tendon recovery, and promoting neuroregeneration.

The peptide works by reducing pro-inflammatory cytokines while promoting anti-inflammatory mediators, creating an optimal regenerative environment.

Research has shown benefits in cardiac protection following myocardial infarction, enhanced muscle fiber repair after strain or trauma, accelerated dermal and epithelial wound healing with reduced scarring, improved joint flexibility and tendon resilience, and potential neuroprotective effects in models of spinal cord and peripheral nerve injury.

However, like BPC-157, TB-500 lacks substantial human clinical trial data and is not FDA-approved for therapeutic use.

It is classified as a prohibited substance by the World Anti-Doping Agency (WADA) and remains designated for research use only.

Quality control concerns exist as it is an unregulated compound in most jurisdictions.

While animal studies suggest it is generally well-tolerated, comprehensive human safety data is limited.

What is Lyophilized Powder?

Lyophilized powder is a sterile, freeze-dried medication that must be reconstituted (mixed with a liquid solvent, like sterile water) before it can be injected. This process extends the drug's shelf life and stability, making it ideal for temperature-sensitive products. The lyophilization process removes water from the peptide in a frozen state through sublimation, which preserves the physical and chemical properties until it is needed.

Application Methods

  • Subcutaneous injection

Product Names

  • TB-500 Peptide
  • Thymosin Beta-4
  • TB-500 Injectable

Benefits

  • Accelerated wound healing and tissue repair
  • Enhanced muscle and tendon recovery
  • Improved joint flexibility and mobility
  • Powerful anti-inflammatory effects
  • Cardiovascular protection and angiogenesis
  • Reduced scar tissue formation
  • Enhanced post-surgical recovery
  • Potential neuroprotective and regenerative effects
  • Improved blood vessel formation
  • Faster recovery from soft tissue injuries

Dosage Levels

  • Subcutaneous - Loading Phase: 2-2.5mg twice weekly for 4-6 weeks
  • Subcutaneous - Maintenance: 2mg once weekly or 5mg every 2 weeks
  • Subcutaneous - Acute Injury: 2.5mg twice weekly for 2-4 weeks, then reduce
  • Can be combined with BPC-157 for enhanced tissue repair
  • Typical cycle: 4-8 weeks loading, followed by maintenance or off-period
  • Inject subcutaneously in abdomen, thigh, or near injury site
  • Reconstitute with bacteriostatic water, store refrigerated 2-8°C
  • Use within 30 days after reconstitution

Research

Where to Buy

*Peptides are stored in form and need to be reconstituted with sterile bacteriostatic water before use.

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Last Updated: 10/19/2025