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RAD140

Not Natty
sarmmuscle gainbreast canceroral

What It Does

Increases muscle and bone mass. Weight gain up to 10% in 28 days. Risk of liver damage and testosterone suppression.

Not Natty Classification

This peptide is classified as NOT natty. It is prohibited by WADA (World Anti-Doping Agency) and most natural bodybuilding federations. Using this compound would place you in the 'enhanced' category rather than natural/natty status in competitive contexts.

Description

SARM (RAD140) for breast cancer trials. Tissue-selective AR modulator. Liver toxicity risk, testosterone suppression. Not FDA-approved, banned in sports.

Full Description

Vosilasarm (RAD140/EP0062) is a selective androgen receptor modulator (SARM) originally developed by Radius Health, now under development by Ellipses Pharma for hormone-sensitive breast cancer (AR+/ER+/HER2-).

Potent, orally-active, nonsteroidal SARM with high androgen receptor affinity (Ki = 7 nM vs 29 nM for testosterone).

Exhibits tissue-selective activity: acts as agonist in skeletal muscle and bone (anabolic effects), but antagonist in prostate and breasts (blocking AR activation and cellular proliferation).

EP0062 reformulation shows markedly improved bioavailability versus original RAD140.

Clinical trials in breast cancer demonstrated 58% stable disease rate and 21% clinical benefit rate at ≥6 months, with marked CA15-3 suppression in 26% of heavily pre-treated patients.

Maximum tolerated dose 100mg daily, with 10mg BID selected as optimal Phase 2 dose.

Originally developed for sarcopenia, osteoporosis, and cancer cachexia but development discontinued for these indications.

Preclinical data showed 90% anabolic potency of testosterone and >10% weight gain in 28 days at 0.1mg/kg in primates.

Concerning safety profile includes documented liver toxicity cases, elevated liver enzymes, 50% testosterone suppression in primates, and negative impacts on skeletal muscle adaptation, frailty, and mortality risk in animal studies.

Not FDA-approved; investigational use only in clinical trials.

Banned by WADA and illegal for non-medical use in many jurisdictions.

Black market products (5-30mg daily doses) pose significant health risks with unknown purity and contaminants.

What is Lyophilized Powder?

Lyophilized powder is a sterile, freeze-dried medication that must be reconstituted (mixed with a liquid solvent, like sterile water) before it can be injected. This process extends the drug's shelf life and stability, making it ideal for temperature-sensitive products. The lyophilization process removes water from the peptide in a frozen state through sublimation, which preserves the physical and chemical properties until it is needed.

Application Methods

  • Oral

Product Names

  • Vosilasarm
  • EP0062

Benefits

  • High androgen receptor affinity (Ki = 7 nM)
  • Tissue-selective: anabolic in muscle/bone, anti-proliferative in breast
  • Clinical benefit in 21% of heavily pre-treated breast cancer patients
  • 58% stable disease rate in breast cancer trials
  • 26% showed marked CA15-3 tumor marker suppression
  • 90% as anabolic as testosterone in preclinical studies
  • >10% weight gain in 28 days in primate models (0.1mg/kg)
  • Oral administration (no injections)
  • Good selectivity over other steroid hormone receptors
  • Reformulated EP0062 has improved bioavailability

Dosage Levels

  • Clinical trials (breast cancer): 50-150mg daily oral
  • Maximum tolerated dose: 100mg daily
  • Phase 2 recommended dose: 10mg twice daily (20mg total)
  • Black market use (not recommended): 5-30mg daily
  • Note: Non-medical use is illegal and dangerous
  • Clinical dosing should only be under medical supervision
  • Liver function monitoring required during use

Research

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Looking for Natty Alternatives?

Since this peptide is classified as not natty, here are some natty-approved options you might consider:

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Increases growth hormone and IGF-1 for 6+ days per injection. Improves body composition, muscle recovery, and fat metabolism. Weekly dosing.
Last Updated: 10/19/2025